منابع مشابه
Studies on monoamine oxidase. (Report XXV). Effects of alcohols on beef liver mitochondrial monoamine oxidase.
The effects of alcohols on MAO activity in beef and rat liver mitochondria were studied. MAO activity was determined manometrically using tyramine (1× 10-2 M) as substrate and expressed as O2 uptake in 60 min. At concentrations of 0.1 to 10%, methanol and ethanol increased MAO activity in both beef and rat liver mitochondria. Activation of MAO by ethanol was reversib...
متن کاملMonoamine oxidase: radiotracer development and human studies.
Monoamine oxidase (MAO) is an integral protein of outer mitochondrial membranes and occurs in neuronal and nonneuronal cells in the brain and in peripheral organs. It oxidizes amines from both endogenous and exogenous sources, thereby influencing the concentration of neurotransmitter amines as well as many xenobiotics. It occurs in two subtypes, MAO A and MAO B, which are different gene product...
متن کاملMonoamine oxidase: radiotracer chemistry and human studies.
Monoamine oxidase (MAO) oxidizes amines from both endogenous and exogenous sources thereby regulating the concentration of neurotransmitter amines such as serotonin, norepinephrine, and dopamine as well as many xenobiotics. MAO inhibitor drugs are used in the treatment of Parkinson's disease and in depression stimulating the development of radiotracer tools to probe the role of MAO in normal hu...
متن کاملFurther studies on the synthesis of A-form monoamine oxidase.
The relation between precursors and restoration of A-form MAO activity in rat liver after administration of clorgyline to rats was investigated by measuring the rates of recovery of A-form MAO activity after treatment with the inhibitor. The half-lives of mitochondrial and microsomal A-form MAO were estimated as 3.5 and 2.0 days, respectively. MAO activity and the amount of MAO molecules were c...
متن کاملInhibition of monoamine oxidase by stilbenes from Rheum palmatum
Seven stilbenes and one catechin were bioactivity-guidedly isolated from the rhizomes of Rheum palmatem. Their structures were identified as piceatannol(1), resveratrol(2), piceid(3), rhapontigenin(4), piceatannol-3'-O-β-D-glucopyranoside(5), rhaponticin(6), catechin(7) and desoxyrhapontigenin(8). Anti-monoamine oxidase (MAO) activities of compounds 1–8 were tested. Compounds 1 and 8 showed sig...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1972
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.68.400